Isotretinoin can provide long-term or even permanent relief from severe acne for many people. It works by reducing the size of oil glands, limiting oil production, and preventing clogged pores. While it’s highly effective, results vary; some individuals may experience a complete, lasting cure, while others might see their acne return, though often less severe. A typical course lasts 4-6 months, and any recurrence can usually be managed with a second treatment or other acne therapies. It’s important to follow your doctor’s advice, as isotretinoin can have significant side effects requiring close monitoring.